Diosmetin is a kind of natural flavonoid compound with strong antioxidant properties, which can enhance the body's ability to resist free radicals after use, and can also be used to prevent skin from ultraviolet radiation and electronic products. A large number of clinical experiments have shown that diosmetin can also improve the ability of PH. Effectively improve the acidity in the body. Secondly, it has bacteriostatic effect. With the development of medical technology, the research on geranthol by medical technology has been continuously deepened. Medical technology believes that this chemical synthesis has a strong antibacterial and bacteriostatic effect after use, which can prevent the growth and spread of bacteria and viruses in the body, and can also reduce the growth of tumors and cancer cells in the body. Finally, geranyl also has the effect of treating eye diseases. With the development of modern life, electronic products have penetrated into every corner of modern life, and many young people in modern life will forget the time to use electronic products, resulting in various diseases of their eyes. Proper use of diosmetin can protect the retina and also improve the appearance of dry eyes. Symptoms of fatigue, watery eyes. Pharmacologic action 1. Anti-tumor effect diosmetin can inhibit the proliferation and promote apoptosis of MCF-7 cells in vitro by activating the JNK apoptotic pathway. Diosmetin inhibited the proliferation of breast cancer MDA-MB468 and normal breast MCF-10a cells. The compound was found to be selective for cancer cells, slightly toxic to normal breast cells, and arrested MDA-MB468 cells in G1 phase. Diosmetin, extracted from traditional Chinese medicine, has been found to possess anticancer activity. 2.Neurological diseasesIn A mouse model of Alzheimer's disease (AD) with tau hyperphosphorylation and cognitive impairment, oral administration of geranitin reduced levels of brain β-amyloid (Aβ) oligomers and increased phosphorylation of inhibitory glycogen synthase kinase 3 (GSK-3β). It also selectively reduces γ-secretase activity, Aβ degeneration, tau hyperphosphorylation, and proinflammatory effects of microglias in vitro. Therefore, diosmetin is thought to have therapeutic effects on AD. 3. Diosmetin can protect retinal cell damage induced by adriamycin (ADR), effectively reduce the ADR-mediated proliferation inhibition and apoptosis of SD rat and human retinal pigment epithelial cells (ARPE-19). Diosmetin inhibited ADR-induced oxidative stress, DNA damage and mitochondrial damage in ARPE-19 cells, reduced ROS level, increased intracellular GDH level, and significantly reversed the expression of Bcl-2 protein induced by ADR in ARPE-19 cells. Therefore, diosmetin may play a protective role in visual acuity by reducing DNA damage and oxidative stress-induced apoptosis of ARPE-19 cells. 4. Liver disease Among citrus fruits, diosmetin has anti-inflammatory and antioxidant effects. In a mouse model of cerulein induced acute pancreatitis (AP), geranyltin pretreatment significantly reduced serum amylase and lipase levels, histological damage, tumor necrosis factor (TNF) -α secretion, interleukin (IL) -1β, IL-6, myeloperoxidase (MPO) activity, and trypsinogen activating peptide (TAP) level. It induces the expression of nitric oxide synthase (iNOS) and activates the NF-κB signaling pathway. Therefore, diosmetin may become a new therapeutic agent in future clinical trials for the treatment of AP. In vitro, diosmetin scavengers free radicals. Therefore, diosmetin has a protective effect on endotoxin-induced acute liver failure in mice by inhibiting NF-κB signaling through antioxidant effect, reducing inflammatory mediators and cytokines, and inhibiting hepatocyte apoptosis. 5.Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common clinical syndrome of diffuse pneumonia with high mortality and limited treatment options. Diosmetin has long been considered an active ingredient in Chinese Herbal medicine due to its antioxidant and anti-inflammatory effects. In human bronchial epithelial cells (HBE), transforming growth factor-β1 (TGF-β1) enhanced EMT and ROS production, while geranyltin significantly inhibited TGF-β1-induced increased cell migration and changes in the expression of n-cadherin, E-cadherin and muscle actin. In addition, geranyltin inhibited TGF-β1-induced intracellular ROS production, PI3K/Akt and MAPK pathways, down-regulated NOX4, and up-regulated SOD and catalase expression. These results demonstrated that geranyltin reduced the process of airway remodeling and fibrosis by inhibiting ROS generation and inactivating PI3K/Akt and MAPK pathways to alleviate TGF-β1-induced EMT. Diosmetin can alleviate the pathological changes of lung tissue, EMT, bronchial asthma, lung injury and other respiratory diseases through anti-inflammatory and antioxidant effects and triggering different signaling pathways. 6. Kidney disease diosmetin pretreatment reduced the inflammatory response and renal tubular cell apoptosis in acute kidney injury, and significantly increased the expression of antioxidant proteins. The renoprotective effects of geranitin involve inhibition of Nf-κB expression and mitochondrial apoptotic pathway and activation of Nrf2/HO-1 pathway. Therefore, geranitin can improve renal injury after renal ischemia/reperfusion.
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