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Ganoderma lucidum, Reishi Mushroom Extract. It is the dried fruiting body of the Polyporaceae fungus Ganoderma lucidum (Leyss. ex Fr.) Karst. or Ganoderma sinense Zhao, Xu et Zhang. It has the effect of tonifying qi and calming the nerves, relieving cough and relieving asthma. Indications for restlessness, insomnia, palpitations, cough and asthma, excessive phlegm, asthenia syndrome, etc.
It was found that Ganoderma Lucidum extract can effectively reduce the cholesterol level of various experimental models in vitro and in vivo. Ganoderic acid A, B and Y were the highest in the organic phase of Ganoderic acid after extraction with ethyl acetate and vacuum evaporation. The extract of Ganoderma lucidum could significantly inhibit cholesterol synthesis of T9A 4 hepatocytes in vitro. Hamsters were fed basal diet supplemented with 2.5% and 5% Ganoderma lucidum extract, respectively. After 18 days of continuous feeding, the levels of total triglyceride, low density lipoprotein and high density lipoprotein in blood of hamsters fed with 2.5% Ganoderma lucidum extract did not change significantly. However, compared with the control group, the hamsters supplemented with 5% Ganoderma lucidum extract had 9.8% lower total triglyceride level and 11.2% lower high density lipoprotein level, while there was no significant change in low density lipoprotein level. The activity of 3-hydroxy-3-methylglutaryl-coA (HMG-COA) reductase was significantly decreased in the liver microsomes of both groups, 52.4% and 33.3% lower than that of the control group. Supplementation of 2.5% Ganoderma lucidum extract to the basal diet of miniature pigs significantly reduced blood triglyceride levels by 12.5% at day 14, and decreased blood triglyceride levels by 20% and low density lipoprotein levels by 27%, but high density lipoprotein levels also decreased by 18% at day 29. At the same time, Ganoderma Lucidum extract can increase the fecal cholesterol and fecal sterol of hamsters and miniature pigs, and reduce the content of cholate. It is speculated that triterpenoids in ganoderma lucidum extract may reduce cholesterol levels by reducing cholesterol synthesis. And the fiber and glucan of Ganoderma may help lower cholesterol levels by affecting cholesterol absorption and bile acid circulation.
The water extract of Ganoderma Lucidum mycelium cultured by deep fermentation can relieve the dyslipidemia of rats fed with high fat diet. After the hyperfat diet was fed for 2 weeks, the water extract of Ganoderma lucidum mycelium (100mg/kg) was given intragastric administration for 4 consecutive weeks, although there was no effect on body weight and liver weight. However, Ganoderma lucidum extract effectively reduced plasma total cholesterol, low density lipoprotein cholesterol, triglyceride and phospholipid levels, and increased high density lipoprotein cholesterol levels in hyperlipidemia rats. At the same time, ganoderma lucidum extract also significantly reduced the levels of total cholesterol, triglyceride and phospholipid in the liver of hyperlipidemia rats.
Shaanxi Huike Botanical Development Co., Ltd. a integrated enterprise which is focus on natural products, plant extract related products and services.We mainly focus on pharmaceutical, functional food, Freeze-dried powder,Natural Pigment,beverages and other business services.
https://www.oasis-hk.com/herbal-medicine/61985115.html
2022-1-9
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