Dyslipidemia is a common clinical metabolic disease with abnormal fat metabolism and transport, and is one of the most important pathogenic risk factors in the development of atherosclerotic cardiovascular disease (ASCVD). Independent risk factors for myocardial infarction. With the development of society and the improvement of people's living standards, the incidence of abnormal blood lipid levels in my country has increased significantly, seriously endangering people's health. According to the guidelines for the prevention and treatment of dyslipidemia in adults in China (2016 revision), the ideal level of low-density lipoprotein cholesterol (HDL-C) in the Chinese population is less than 2.6 mmo/L (100 mg/dl), non-high-density lipids The ideal level of protein cholesterol (non-high-density lipoprotein cholestrol, non-HDL-C) is less than 3.4mmo/L (130mg/dl).
Studies have found that Ganoderma lucidum extract can effectively reduce cholesterol levels in a variety of in vitro and in vivo experimental models. Ganoderma lucidum fruit bodies were extracted with ethyl acetate, and the organic phase obtained by vacuum evaporation was mainly composed of Ganoderma lucidum triterpenoids, among which ganoderic acid (ganoderic acid) A, B and Y content were the highest. The Ganoderma lucidum extract can significantly inhibit the cholesterol synthesis of T9A4 hepatocytes in vitro. After 2.5% and 5% of Ganoderma lucidum extract were added to the basal diet of hamsters, it was found that after 18 days of continuous feeding, the levels of blood total triglyceride, low-density lipoprotein and high-density lipoprotein of hamsters in the 2.5% Ganoderma lucidum extract group were the same. There was no significant change, but the total triglyceride level of the hamsters in the 5% Ganoderma lucidum extract group was reduced by 9.8% compared with the normal diet control group, and the level of high-density lipoprotein was also reduced by 11.2%, and the level of low-density lipoprotein did not appear significant. Variety. The activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase was significantly decreased in the liver microsomes of both groups of hamsters, which were 52.4% and 33.3% lower than those of the normal diet control group, respectively. Adding 2.5% Ganoderma lucidum extract to the basal diet of miniature pigs, feeding to the 14th day, the blood triglyceride level can be significantly reduced by 12.5%, and feeding to the 29th day, the blood triglyceride level can be significantly reduced by 20%, low density Lipoprotein levels were reduced by 27%, but high-density lipoprotein levels were also reduced by 18%. At the same time, Ganoderma lucidum extract can increase fecal cholesterol and fecal sterol in hamsters and miniature pigs, and reduce bile salt content. It is speculated that the triterpenoid components in Ganoderma lucidum extract may reduce cholesterol levels by reducing cholesterol synthesis. And the fiber content and glucan of Ganoderma lucidum may help lower cholesterol levels by affecting cholesterol absorption and bile acid circulation. The water extract of Ganoderma lucidum mycelium cultured by submerged fermentation can alleviate dyslipidemia in high-fat diet-fed rats. After 2 weeks of high-fat diet feeding to induce dyslipidemia, the water extract of Ganoderma lucidum mycelium was given by gavage for 4 consecutive weeks. (100mg/kg), although it had no effect on body weight and liver weight, Ganoderma lucidum extract effectively reduced plasma total cholesterol, low-density lipoprotein cholesterol, triglyceride and phospholipid levels in hyperlipidemia rats, and increased high-density lipoprotein levels. Cholesterol levels. At the same time, Ganoderma lucidum extract also significantly reduced the levels of total cholesterol, triglycerides and phospholipids in the liver of hyperlipidemic rats.
Shaanxi Huike Botanical Development Co., Ltd. a integrated enterprise which is focus on natural products, plant extract related products and services.We mainly focus on pharmaceutical, functional food, Freeze-dried powder,Natural Pigment,Homology of medicine and food,beverages and other business services.
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2022-3-21
Shaanxi Huike Botanical Development Co., Ltd.
